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Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1.

Treatment may continue for up to four weeks for patients who have a higher risk of blood clots.

Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois; the Australian Graduate School of Management, University of New South Wales and the University of Sydney, Sydney, Australia; the Department of Nephrology, Tenon Hospital and Pierre and Marie Curie University, Paris, France; the Departments of Medicine and Oncology, McGill University Health Center, Montreal, Quebec, Canada; the University of New Mexico, VA Cooperative Studies Program, Albuquerque, New Mexico; the Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California; and Hotel Dieu Hospital and INSERM U362, Department of Hematology, Paris, France.

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In preclinical studies asialo-Epo (Epo lacking terminal sialic acid) and carbamoylated Epo (CEPO, Epo treated with cyanate) were assigned cytoprotection without stimulating erythropoiesis.

Association between serum levels of C-reactive protein and response to treatment of chemotherapy-induced anemia in patients with solid tumors: a multicenter, prospective, observational study.

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The protein formulations were characterized using far-UV CD, Trp intrinsic fluorescence, ANS extrinsic fluorescence and static light scattering, and the data as a function of pH and temperature were obtained for the construction of CSDs.

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ESAs are an important treatment option for patients with certain types of anaemia, including chemotherapy-induced anaemia and anaemia due to chronic kidney disease.

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Protein characteristics that affect the potential for both viscosity and aggregate formation include hydrophobicity, charge patches and dipole interactions, and self-association.

Indeed, it is possible that erythropoietin as a ligand may be interacting with cells through other receptors as well as erythropoietin receptors.

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Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3-specific receptor beta-chain-null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor.

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As such, most of the registration trials for FDA approval were relatively small and conducted in heterogeneous patient populations with a mixture of primarily solid tumors at various stages who were undergoing treatment with a variety of regimens.

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Darbepoetin alfa (rINN) is a synthetic form of erythropoietin.

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Biosimilars developed and marketed are not without risk, especially from legal challenges.

Withdrawal of rHuEPO followed by treatment with immunosuppressives (cyclosporine A) for several months rendered patients anti-EPO antibody negative and transfusion independent.

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This illustrates the dangers of failing to understand the relative immunopharmacology (especially potency and downstream effects of signaling) between animals and humans.

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Children with chronic renal failure should start their dosage for anemia at 50 units per kilogram of their body weight, and the medication should be given three times a week.

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Successful reintroduction of a different erythropoiesis-stimulating agent after pure red cell aplasia: relapse after successful therapy with prednisone.

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Failure of combination therapy with recombinant granulocyte colony-stimulating factor and erythropoietin in myelodsyplastic syndromes.

The erythropoietin hormone level can be detected and measured in the blood (the EPO test).

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Epoetin alfa for the treatment of the anemia of multiple myeloma: a prospective, randomized placebo-controlled, double-blind trial.

Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (HIV-1): a treatable cause of anemia in AIDS.

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